Have you ever tried to copy and paste substitutions in server's names.nsf? I'm having problem there for last few years (if I recall correctly). Problem is quite simple, after you tried to paste substitution your Lotus Notes always freeze.
Previously I used ctrl+pause to avoid this freeze but I got new laptop and pause is absent :) (and I do not know how to simulate ctrl+pause).
Hope IBM will fix that in 8.5.3 :)